This study is concentrated on Ludlow (to Pridoli?) miospores from the Los Espejos Formation at the Quebrada Ancha locality, Central Precordillera, San Juan Province, Argentina. The Ludlow age is in agreement with the age based on acritarchs. The assemblage of continental palynomorphs is composed of 43 miospore species (29 trilete spores and 14 cryptospores). A new synonymy is proposed: Chelinospora poecilomorpha is here considered a junior synonym of Clivosispora verrucata. In addition, specimens belonging to C. verrucata var. verrucata and C. verrucata var. convoluta are included in a new morphon. This study represents the second Late Silurian miospore assemblage described from South America; the first was from the Urubu River, Amazon Basin, northern Brazil. The Quebrada Ancha assemblages allow a reasonably good correlation with biozones established for the Upper Silurian from the Cantabrian Mountains, northern Spain. The dendrogram analysis between coeval miospore assemblages from different localities shows a strong palaeogeographic affinity with the miospores recovered from northern Brazil and North Africa. Miospore assemblages from Spain show influences from Baltica and North Africa, demonstrating their intermediate position between these two continental plates. Conversely, dissimilarities recognized between Libya and Tunisia are most probably owing to local ecology and/or environmental conditions.