Long neglected, Gaetano Salvemini's years of exile (1925–1949) now constitute a crucial period for reconsidering his intellectual and political profile. This article intends first to propose an overall interpretation of Salvemini's exile that considers the years 1919 to 1925 as the culmination of a profound turning point in his life. The central part of the essay is devoted to reconstructing the genesis of Salvemini's relationship with the United States and dwells on the reflections written after his first trip overseas in 1927. In them it is possible to find a clear analysis of the impact of Fascist propaganda on American soil and a definition of the tasks that exiles were called upon to perform in their host countries. Building on these premises, the study rereads Salvemini's years of American exile by focusing on three aspects. Firstly, his great ability to adapt to the American academic world. Secondly, his commitment to the field of research, with works dedicated to the study of Fascism, some centred on a reinterpretation of the concept of democracy and others on the methodology of history. Thirdly, his prodigious activity carried out in the antifascist struggle.