In A Treatise of Human Nature, David Hume claims that causes must temporally precede their effects. However, his main argument for this claim has long puzzled commentators. Indeed, most commentators have dismissed this argument as confused, but beyond this dismissal, the argument has provoked relatively little critical attention. My aim in this paper is to rectify this situation. In what follows, I (i) clarify the argument’s interpretive challenges, (ii) critique two existing interpretations of it, and (iii) offer my own improved interpretation. More generally, I hope to throw new light on this puzzling aspect of Hume’s philosophy.