Field studies were conducted to determine the effect of halosulfuron at 0, 13, 26, 39 or 52 g ha−1 applied 10, 22, and 31 d after planting (DAP) on ‘Beauregard' and ‘Covington' sweetpotato. Storage roots were harvested, graded, cured, and stored in controlled environment for 2 mo. Where injury on storage roots was observed, external injury occurred on the surface of the storage root as a blackened area with blistering and internal injury consisted of small red-brown spots inside the sweetpotato storage root. Total yield of sweetpotato with 13 g ha−1 halosulfuron treatment (155,157 kg ha−1) was similar to the nontreated check (162,002 kg ha−1). However, halosulfuron rates above 13 g ha−1 resulted in a reduction of marketable grade roots and total yield of sweetpotato. Regardless of rate and timing of halosulfuron, external and internal injury to Beauregard storage roots was less than 6 and 9%, respectively. No external injury to Covington was observed from all rates of halosulfuron applied POST at 10 DAP. Halosulfuron at 22 DAP to Covington caused greater external injury to storage roots than was observed on the nontreated. Thus, Beauregard appears more tolerant to halosulfuron POST than Covington. To minimize internal or external injury to storage roots of Covington, halosulfuron must be applied within 10 DAP.