Laboratory studies were conducted to determine the ability of the extenders dietholate and SC-0058 to prevent enhanced biodegradation of EPTC and butylate applied to Wisconsin soils with different histories of carbamothioate herbicide use. Enhanced EPTC and butylate biodegradation occurred in soils previously treated with those herbicides. Enhanced biodegradation of dietholate occurred on soils previously treated with that extender plus either EPTC or butylate. Enhanced dietholate biodegradation was observed when applied alone or in combination with butylate or EPTC. Application with dietholate prevented enhanced biodegradation of butylate but not EPTC even though enhanced biodegradation of dietholate was occurring. Enhanced biodegradation of SC-0058 did not occur. SC-0058 prevented enhanced EPTC and butylate biodegradation even in soils previously treated for three consecutive years with the respective herbicide plus SC-0058. Application of either 1.1 or 2.2 kg/ha SC-0058 plus 6.7 kg/ha EPTC provided equal or better wild proso millet control and sweet corn yields than applications of EPTC alone or EPTC plus dietholate.