Field studies were conducted in 1991 to 1993 to determine the effects of PRE and POST herbicides alone and in factorial combinations on sicklepod control, weed biomass, and soybean seed yields. Herbicides evaluated were metribuzin PRE, metribuzin + chlorimuron PRE, imazaquin PRE and POST, chlorimuron POST, and AC 263,222 POST POST herbicides alone provided better sicklepod control than PRE herbicides alone. However, sequential (SEQ) treatments [PRE followed by (fb) POST] provided better sicklepod control than single herbicide treatments. Metribuzin and metribuzin + chlorimuron alone or used in a SEQ program provided similar PRE control of sicklepod, and both controlled sicklepod better than imazaquin in 1991 and 1992. Chlorimuron alone or in a SEQ program provided better POST control than AC 263,222 or imazaquin alone when soil moisture levels at planting favored weed seed germination. When soil moisture levels at planting were unfavorable for weed seed germination, the residual activity of imazaquin provided the best season-long control. SEQ herbicide applications allowed soybean to attain higher seed yields than single (PRE or POST) herbicide treatments all 3 yr. However, only metribuzin fb chlorimuron in 1991 and 1992 and imazaquin fb imazaquin and imazaquin fb chlorimuron in 1993 allowed soybean to achieve seed yields similar to weed-free soybean. Soybean seed yields were greater with POST than with PRE herbicides 2 of 3 yr, but no single herbicide treatment provided soybean seed yields similar to weed-free soybean.