Two field experiments were established in 1988 and 1989 in southeast Missouri to evaluate several herbicides and herbicide combinations for giant ragweed control in soybean. In 1988, a timely rainfall was not received for soil-applied herbicides and giant ragweed control was less than 75%. However, in 1989 soil moisture was sufficient for uptake of soil-applied herbicides and early season giant ragweed control was generally greater than 80%. Chlorimuron, chlorimuron plus 2,4-DB, imazaquin plus 2,4-DB, acifluorfen followed by naptalam plus 2,4-DB, fomesafen, and imazethapyr applied to 2.5 to 5-cm giant ragweed controlled more than 85% in 1988. In 1989, all POST treatments except imazaquin controlled more than 81% of giant ragweed 2 wk after treatments. Imazethapyr controlled seedling giant ragweed at heights up to 12 to 25 cm. Giant ragweed regrowth and/or reinfestation and giant ragweed seed production occurred with all herbicide treatments.