This study seeks to identify the social factors related to opposition to government regulation of agricultural chemicals and pharmaceuticals. Analysis of data from a 1982 survey of farm operators in New York State shows that, in contrast to much of the literature that represents farmers as being almost universally opposed to regulation, farm operators' orientations toward government regulation of these substances vary considerably. Indicators of the class status or position of farm operators were found to be directly related to opposition to regulation. Willingness to assume risk and the importance placed by farm operators on making profit were also directly related to opposition to regulation, while farm men's off-farm work, cynicism toward agribusiness, non-economic orientation toward agriculture, perceptions of potential side effects of agricultural chemicals and drugs, and liberal political attitudes were inversely related to opposition to regulation. The results of a multivariate analysis suggest that farmer opposition to government regulation of agricultural chemicals is primarily due to farmer ideology and has little relationship with whether farmers actually use these chemicals.