Field experiments were established in 1989 and 1990 on silty clay and sandy loam soils to evaluate selective herbicides in combination with non-selective weed control measures in conventional and stale seedbed soybean production. Metribuzin PRE followed by chlorimuron POST controlled sicklepod better with paraquat than with glyphosate. A POST application of imazaquin increased sicklepod and pitted morningglory control by imazaquin PRE alone in a stale seedbed or tillage program. Pitted morningglory control with imazaquin PRE was lower with tillage than with glyphosate or paraquat combinations in a stale seedbed program. All metribuzin plus chlorimuron PRE treatments, whether conventional tillage or stale seedbed, controlled pitted morningglory more than 75%. Hemp sesbania control was above 80% with all metribuzin followed by chlorimuron or metribuzin plus chlorimuron PRE combinations, and less than 70% with all treatments containing imazaquin. Selective herbicides increased yield in stale seedbed when glyphosate or paraquat was added. Imazaquin PRE, imazaquin PRE followed by imazaquin POST, and metribuzin PRE followed by chlorimuron POST tank mixed with glyphosate or paraquat in a stale seedbed program increased yield compared with the same treatments used with tillage.