This article argues that Flowers (flores sanctorum), collections of saints’ lives arranged by the liturgical calendar, were the first genre of devotional literature to have a global reach during the sixteenth and seventeenth centuries. This article begins with the medieval origins of Flowers before analysing their dispersion in the sixteenth and early seventeenth centuries by the Franciscans and Jesuits. By taking a temporal long view and a transoceanic perspective, the article contributes to the scholarship on early modern evangelization, translation, global networks, and the historiographies of the Franciscans and Jesuits.