The past decade saw the proliferation of projects that use 3D and related technologies to engage with Indigenous heritage through museum collections and cultural heritage site digitization projects involving the documentation and sometimes physical replication of objects and landscapes; some of these projects involved Indigenous origin communities. Although 3D technologies have become more widespread and accessible, ethical considerations in practice lag behind. The “Ethical Considerations in Three-Dimensional Digitization of Indigenous Heritage” project unites researchers, members of Indigenous communities, and 3D heritage specialists to develop a set of best practices for the responsible conduct of research (RCR). These practices promote ethical cultures in science, technology, engineering, and math (STEM) fields, recognizing Indigenous heritage 3D modeling as a critical part of the broader conversation around decolonization and core methodologies. This article proposes incorporating best practices developed from the RCR findings for 3D digitization projects of Indigenous cultural heritage. We suggest utilizing Collective benefit, Authority to control, Responsibility, and Ethics (CARE) principles, Indigenous Data Sovereignty, and a co-production of knowledge (CPK) framework.