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1 results

  • Case 17 - “I Feel Very Lonely”

  • Matthew Gibfried, Saint Louis University School of Medicine, Missouri, George T. Grossberg, Saint Louis University School of Medicine, Missouri
  • Book:
    Clinical Case Studies in Long-Term Care Psychiatry
    Published online:
    31 October 2024
    Print publication:
    14 November 2024, pp 83-87

  • Summary

    A major influence on positive or negative therapeutic responses to a medication is the drug’s metabolism in a given individual. The metabolism of pharmaceuticals is influenced by age-related factors. Lithium, valproic acid, and carbemazepine levels are still important to obtain periodically when these drugs are used in the management of bipolar disorder and some other psychiatric and neurologic conditions. The metabolism and serum concentrations of medications do not always correlate well with clinical response. At this time pharmacogenetic information used to guide antidepressant therapy does not consistently show improved outcomes. Some studies show improved outcomes and some show no difference in outcomes.