Several types of pre-solar grains, grains that existed prior to solar system formation, have been found in the fine-grained components of primitive meteorites, interplanetary dust particles (IDPs), and comet samples. Known pre-solar components have isotopic compositions that reflect formation from the ejecta of evolved stars. Other pre-solar materials may have isotopic compositions very similar to solar system materials, making their identification as pre-solar grains problematic. Pre-solar materials exhibit a range of chemical and thermal resistance, so their relative abundances can be used to probe the conditions in the solar nebula. Detailed information on the relative abundances of pre-solar and solar-system materials can provide information on the temperatures, radiation environment, and degree of radial mixing in the early solar system.