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2 results

  • 1 - Physician Heal Thyself

  • Daniel Gibbs, Emeritus of Oregon Health and Science University
  • Book:
    Dispatches from the Land of Alzheimer's
    Published online:
    19 January 2024
    Print publication:
    22 February 2024, pp 5-8
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  • Summary

    An email with a black box warning! That’s what I got 11 years ago after Lois and I submitted saliva samples to a DNA testing service. Lois is the family genealogist, and she thought that DNA testing would be helpful in filling in some of the missing branches of our ancestral trees. In addition to lists of DNA relatives, the report included many risk genes for a variety of medical conditions, none of which were present for either of us. However, this locked black box contained two genes of neurological interest. A mutation in the LRRK-2 gene is the most common cause of hereditary Parkinson’s disease, and the APOE-4 allele is the most significant genetic risk factor for late onset Alzheimer’s disease.

  • Smelling different after COVID-19 ?

  • K. Nourchene, E. Khelifa, B. Abassi, I. Bouguerra, O. Maatouk, S. Ben Aissa, L. Mnif
  • Journal:
    European Psychiatry / Volume 65 / Issue S1 / June 2022
    Published online by Cambridge University Press:
    01 September 2022, p. S514
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      • Open access
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  • Introduction

    Over the course of COVID 19 illness, olfactory dysfunction was largely described as hyposmia and anosmia. What about phantosmia?

    Objectives

    In this study, we aimed to explore olfactory hallucinations among COVID 19 patients.

    Methods

    Our literature review was based on the PubMed interface and adapted for 2 databases: Science Direct and Google Scholar using the following combination ( phantosmia [MeSH terms]) OR (olfactory hallucinations[MeSH terms]) AND (COVID-19 [MeSH terms]).

    Results

    Smell dysfonction is one of the most revealing sign of COVID 19 infection. However, other symptoms particularlty phantosmia tend to emerge later in the course of the disease. Female predominance was noted among patients sufferning from olfactory hallucinations regardless to their medical history. An unpleasant olfactory sensation was the most described sign. The occurene of phantosmia was also described in one case of women suffering from schizophrenia whom tested positive for COVID 19 infection.

    Conclusions

    Olfactory hallucinations are more and more associated with COVID-19 disease regardless to psychiatric disorders. The pathological mechanism remains unclear and further studies are needed for a better comprehension and management.

    Disclosure

    No significant relationships.