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In acute ischemic stroke, a longer time from onset to endovascular treatment (EVT) is associated with worse clinical outcome. We investigated the association of clinical outcome with time from last known well to arrival at the EVT hospital and time from hospital arrival to arterial access for anterior circulation large vessel occlusion patients treated > 6 hours from last known well.
Methods:
Retrospective analysis of the prospective, multicenter cohort study ESCAPE-LATE. Patients presenting > 6 hours after last known well with anterior circulation large vessel occlusion undergoing EVT were included. The primary outcome was the modified Rankin Scale (mRS) score at 90 days. Secondary outcomes were good (mRS 0–2) and poor clinical outcomes (mRS 5–6) at 90 days, as well as the National Institutes of Health Stroke Scale at 24 hours. Associations of time intervals with outcomes were assessed with univariable and multivariable logistic regression.
Results:
Two hundred patients were included in the analysis, of whom 85 (43%) were female. 90-day mRS was available for 141 patients. Of the 150 patients, 135 (90%) had moderate-to-good collaterals, and the median Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7–10). No association between ordinal mRS and time from last known well to arrival at the EVT hospital (odds ratio [OR] = 1.01, 95% CI = 1.00–1.02) or time from hospital arrival to arterial access (OR = -0.01, 95% CI = -0.02–0.00) was seen in adjusted regression models.
Conclusion:
No relationship was observed between pre-hospital or in-hospital workflow times and clinical outcomes. Baseline ASPECTS and collateral status were favorable in the majority of patients, suggesting that physicians may have chosen to predominantly treat slow progressors in the late time window, in whom prolonged workflow times have less impact on outcomes.
Nutrition support involves the use of oral supplements, enteral tube feeding or parenteral nutrition. These interventions are considered when oral intake alone fails to meet nutritional requirements. Special diets and oral supplements are usually the first approach to managing malnutrition; however, their role becomes limited when oral intake is restricted or if swallowing is unsafe. Enteral tube feeding or parenteral nutrition are alternative means of providing nutrition support for this select group of patients. Percutaneous endoscopic gastrostomy (PEG) feeding was introduced into clinical practice in 1980. It describes a feeding tube placed directly into the stomach under endoscopic guidance. It is an established means of providing enteral nutrition to those who have functionally normal gastrointestinal tracts, but who cannot meet their nutritional requirements due to inadequate oral intake. The intervention is usually reserved when nutritional intake is likely to be inadequate for more than 4–6 weeks. Although the benefits of PEG have been shown for a select group of patients, there currently exists concerns about the increasing frequency of this intervention, and also uncertainty about the long-term benefits for certain patients. The 2004 UK National Confidential Enquiry into Patient Outcome and Death report emphasised this concern, with almost a fifth of PEG being undertaken for futile indications that negatively influenced morbidity and mortality. The present review paper discusses the indications for, controversies surrounding and complications of gastrostomy feeding and provides practical advice on optimising patient selection for this intervention.
Facial transplantation is emerging as a therapeutic option for self-inflicted gunshot wounds. The self-inflicted nature of this injury raises questions about the appropriate role of self-harm in determining patient eligibility. Potential candidates for facial transplantation undergo extensive psychosocial screening. The presence of a self-inflicted gunshot wound warrants special attention to ensure that a patient is prepared to undergo a demanding procedure that poses significant risk, as well as stringent lifelong management. Herein, we explore the ethics of considering mechanism of injury in the patient selection process, referring to the precedent set forth in solid organ transplantation. We also consider the available evidence regarding outcomes of individuals transplanted for self-inflicted mechanisms of injury in both solid organ and facial transplantation. We conclude that while the presence of a self-inflicted gunshot wound is significant in the overall evaluation of the candidate, it does not on its own warrant exclusion from consideration for a facial transplantation.
It is not clear how to effectively recruit healthy research volunteers.
Methods
We developed an electronic health record (EHR)-based algorithm to identify healthy subjects, who were randomly assigned to receive an invitation to join a research registry via the EHR’s patient portal, letters, or phone calls. A follow-up survey assessed contact preferences.
Results
The EHR algorithm accurately identified 858 healthy subjects. Recruitment rates were low, but occurred more quickly via the EHR patient portal than letters or phone calls (2.7 vs. 19.3 or 10.4 d). Effort and costs per enrolled subject were lower for the EHR patient portal (3.0 vs. 17.3 or 13.6 h, $113 vs. $559 or $435). Most healthy subjects indicated a preference for contact via electronic methods.
Conclusions
Healthy subjects can be accurately identified from EHR data, and it is faster and more cost-effective to recruit healthy research volunteers using an EHR patient portal.
This chapter addresses issues related to patient selection and preparation prior to undergoing assisted reproductive technology (ART) techniques, and the role of regulatory control in ART and welfare of the child assessment. It discusses the special aspects of ART including gamete and embryo donation, pre-implantation genetic screening (PGS) and diagnosis (PGD) and fertility preservation. Before the processing of patient gametes or embryos, the couple should be screened for hepatitis B, hepatitis C and HIV to assess their risk of cross-contamination. In the UK, the regulatory control of ART lies with the Human Fertilisation and Embryology Authority (HFEA). The risk of implantation failure and pregnancy loss secondary to aneuploidy increases with advanced maternal age, particularly after the age of 35 years. Fertility preservation described in the chapter includes sperm cryopreservation, oocyte cryopreservation, and ovarian tissue cryopreservation.
This chapter covers pre-screening, history and physical for evaluation of patients who are potential candidates for procedures under sedation, as well as instructions for patients. Patients for elective procedures may be referred by their primary care physician or may be self-referred. Screening, evaluation, and instruction of patients requires clinical experience, and clerical staff members should not be performing any more than simple initial screening or instructing patients as to time, location, and routine standard instructions. The scope of practice of the surgeon/practitioner/physician(s) involved and the individual facility determine the range of procedures possible. The setting may be quite flexible and general (an operating room) or very specifically designed and equipped. Procedures should be scheduled in locations equipped both for the procedure and for sedation and any contingencies that can be routinely expected as a result of either the procedure or the patient.
This chapter details factors that should be considered when evaluating each patient's candidacy for deep brain stimulation (DBS). A number of factors need to be assessed in a systematic matter to determine each patient's candidacy for treatment with DBS. Parkinson's disease (PD) patients referred for surgery are at greater risk for psychotic symptoms, as they usually have relatively advanced disease. When considering a patient with essential tremor (ET) for DBS, it is important to make sure the patient meets clinical criteria for the diagnosis of ET as a first step. Determining which dystonia patients are candidates for DBS can be challenging than making this determination for patients with PD or ET. An effective method for arriving at decisions regarding the candidacy of patients for treatment with DBS is to collect the required data for each patient and then convene a conference. These details are discussed by the interdisciplinary/multidisciplinary team.
Background: Cognitive Behaviour Therapy self-help has been recommended in the NICE guidelines for the treatment of anxiety and depression. However, little is known about who benefits from self-help and the potential drawbacks and problems of using this approach. Aims: To address the current gap in knowledge, we contacted accredited BABCP practitioners to examine practitioner use and attitudes to self-help, current trends of use, and to identify possible problems with this therapy. Method: A 50% random sample of all accredited BABCP practitioners was approached, and the overall response rate for the survey was 57.6%. Results: Self-help materials were seen positively by therapists and were used by 99.6%, mainly as an adjunct to individual therapy. Only 38.2% had been trained in the use of self-help, with those trained being more likely to recommend self-help. Higher levels of patient motivation, credibility, likely adherence, self-efficacy and a lower degree of hopelessness were the five factors identified by more than 70% of respondents as predicting successful patient outcome with self-help. Non-compliance and a lack of detection of a worsening of the patient's clinical state due to reduced therapist contact were viewed as being the most important problems with self-help by more than 70% of respondents. Conclusions: Preferable patient characteristics for self-help have been identified, as have potential problems and adverse consequences.
This chapter reviews the current assisted reproductive technology (ART) outcome analysis process in the United States to expand the reader's perspective and understanding of its complexity and explores progress toward meaningful collection, analysis, and interpretation of ART outcomes by clinician and patient in the future. The Society for Assisted Reproductive Technology (SART), an affiliate organization of the American Society for Reproductive Medicine (ASRM), worked with the Centers for Disease Control and prevention (CDC) as the initial purveyor of data collection and publication, representing reproductive specialists and the majority of domestic ART practices. Ovarian reserve, diagnosis-specific therapy, laboratory prowess, practice management philosophies, therapeutic access, and patient demographics play an intricately intertwined role in determining successful outcome. Patient selection/rejection is acknowledged as powerful influences of ART outcome but is practiced to different degrees by any individual physician/practice.
Ambulatory surgery is growing worldwide. The challenge of providing anaesthesia for longer and more complex surgery in sicker and elderly patients is a reality. To maintain the safety and good outcomes of ambulatory anaesthesia, high-risk patients will need to be evaluated carefully. Anaesthetic techniques that use short-acting drugs and minimize postoperative morbidity and mortality should become the focus. Policies on management of postoperative pain, nausea, vomiting, voiding and discharge from hospital will maintain good outcome measures.
Clinical practice guidelines are expanding their scope of authority from clinical decision making
to collective policy making, and promise to gain ground as resource allocation tools in coming
years. A close examination of how guidelines approach patient selection criteria offers insight
into their ethical implications when used as resource allocation or rationing instruments. The
purposes of this paper are: a) to examine the structure of allocative reasoning found in clinical
guidelines; b) to identify the ethical principles implied and compare how guidelines enact these
principles with how explicit systems-level rationing exercises and health policy analyses have
approached them; and c) to offer some preliminary suggestions for how these ethical issues
might be addressed in the process of guideline development. The resulting framework can be
used by guideline developers and users to understand and address some of the ethical issues
raised by guidelines for the use of scarce technologies.
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