This chapter considers Romantic surgery from the patient’s perspective. It uses Astley Cooper’s rich archive of personal correspondence to explore the complex emotions associated with the experience of surgical illness and its treatment, as well as the ways in which emotional expression functioned as a form of agency within the private surgical relationship. In addition to considering private patients, this chapter also examines how emotions expressed and mediated agency within what, following Michel Foucault, we might consider the ‘disciplinary’ space of the hospital. The pre-anaesthetic surgical patient was a deeply unstable and ‘messy’ ontological entity whose pre-operative health and post-operative recovery were determined by a complex melding of constitutional, nervous, and emotional factors. Thus, as this chapter demonstrates, the patient’s own body could exert an unconscious material agency, often frustrating both surgical intervention and the patient’s own will, something that was most evident in the associations between irritability and obstreperousness that characterised contemporary discourses on amputation and its discontents.