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1 results

  • Vaccination with hatched but non-activated, non-viable oncospheres of Taenia taeniaeformis in rats

  • A. Ito, A. Hashimoto
  • Journal:
    Journal of Helminthology / Volume 67 / Issue 2 / June 1993
    Published online by Cambridge University Press:
    05 June 2009, pp. 165-168

  • The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a Taenia taeniaeformis/rat system, since preparation of these oncospheres in vitro is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.