Sequential applications of MSMA plus metribuzin with selected plant growth regulators interacted synergistically and increased injury of ‘Tifway’ bermudagrass 1 and 2 wk after treatment. However, the higher injury at 3 wk after treatment, from sequential MSMA plus metribuzin with flurprimidol plus mefluidide or paclobutrazol with mefluidide, was additive. The vegetative growth suppression of bermudagrass at 2 wk after treatment with 2,4-D plus mecoprop plus dicamba with flurprimidol was antagonistic. The higher growth suppression 2 wk after treatment for MSMA plus metribuzin and flurprimidol plus mefluidide was additive compared to flurprimidol with mefluidide alone.