Field trials were conducted in 1985, 1986, and 1987 to identify effective herbicide treatments to control mayweed chamomile in winter wheat. Dicamba at 280 g ae/ha, 2,4-D at 560 g ae/ha, and bromoxynil at 560 g ai/ha did not control 11-cm-tall or larger mayweed chamomile and inconsistently controlled smaller plants. Mayweed chamomile control generally declined with increasing weed size. DPX-M6316 at 8.8 g ai/ha and DPX-L5300 at 4.4 g ai/ha controlled 89% or more mayweed chamomile. CGA-131036 at 4.9 g ai/ha controlled 95% or more mayweed chamomile. DPX-M6316, DPX-L5300, and CGA-131036 controlled 3- to 18-cm-tall mayweed chamomile similarly.