The north-west Tibetan Plateau in China is currently undergoing development-related changes in land use that illustrate a significant mismatch between national/international conservation objectives and national livestock and other rangeland development goals for the region. Areas designated as nature reserves are being subjected to the same livestock development policies as elsewhere on the Plateau, including interventions that are detrimental to the supposedly protected wildlife populations. Unintended effects of some livestock development activities, such as the fencing of winter grazing areas and resultant enhancement of illegal hunting, have been little considered in overall development actions inside the nature reserves. We address these issues within the 300,000 km2 Chang Tang Nature Reserve, covering much of the north-west Plateau, and concentrate on Gertse County in the western part of the Reserve. There are still tens of thousands of Tibetan antelope Pantholops hodgsonii, Tibetan gazelle Procapra picticaudata, kiang Equus kiang and other species in the north-west Chang Tang, and long-distance antelope calving migrations are still relatively intact. However, increasing human and livestock populations, new rangeland management initiatives, effects of mining activity and continued hunting have the potential to counter conservation initiatives even in the most critical areas for wildlife in the region. Within the nature reserves livestock carrying capacity determinations that allow for wildlife needs and recognize the variable climate are essential. Livestock fencing amenable to wildlife movement, a ban on fencing in areas critical to wildlife, and other actions that mitigate negative effects on wildlife are needed in nature reserves where antelope and other species are still abundant.