Greenhouse studies determined dose responses of winter annual weeds and winter wheat to preemergence (PRE) and postemergence (POST) treatments of MKH 6561 and the residual effects on kochia. MKH 6561 at 11 to 45 g ha−1 did not affect wheat. MKH 6561 at 11, 34, and 45 g ha−1 reduced winter annual weed densities compared to an untreated control. Weed growth was inhibited as the rate of MKH 6561 was increased, but downy brome, cheat, and Japanese brome were three to six times more susceptible than jointed goatgrass. The GR70 values for cheat, downy brome, Japanese brome, and jointed goatgrass were 7, 11, 4, and >45 g ha−1, respectively. Dry weights of kochia seeded after removal of the winter annual grasses decreased as MKH 6561 rate increased, with average control being 77% compared to the nontreated control. Regression analysis indicated that kochia was controlled 80% with MKH 6561 at 28 g ha−1.