Inbreeding coefficients were determined for nine southeastern Idaho kochia populations using chlorsulfuron resistance as a phenotypic marker. Inbreeding coefficients in six of the populations approximated 0, indicating that these field populations were random mating. One population had an inbreeding coefficient of 0.32, indicating partial selfing. No susceptible genotypes were identified in one population, which suggested recent selection and skewed the inbreeding coefficient. One population had an inbreeding coefficient of −0.19, suggesting either heterozygote advantage or some recent selection in the population. Our results suggest that kochia populations generally approximate random mating. Therefore, unlinked alleles will be independently assorted in field populations of kochia.