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1 results

  • Urinary incontinence and diarrhoea associated with the switch from oral to injectable risperidone

  • Enrica Di Rosa, Daniela Caldirola, Achille Motta, Giampaolo Perna
  • Journal:
    Acta Neuropsychiatrica / Volume 25 / Issue 2 / April 2013
    Published online by Cambridge University Press:
    21 February 2013, pp. 119-121
  • Objective

    Urgency, urinary incontinence and bowel disturbances are distressing side effects that have been observed during treatment with risperidone and other antipsychotics probably due to the receptor affinity profile. This occurrence can lead to poor compliance and therefore impair clinical outcome.

    Method

    We report the case of a 50 year‐old lady, who experienced urinary incontinence and diarrhoea, when switching from oral to injectable risperidone, which ceased when discontinuing the drug.

    Results and conclusions

    It should be taken into account that some side effects can be revealed when switching from oral to depot formulations due to non‐compliance to orals; nevertheless dose‐dependent mechanisms and individual metabolic variability must be considered when observing idiosyncratic reactions to drugs.