Background: Inflated responsibility is the main feature of cognitive-behavioural models of obsessive-compulsive disorder (OCD). However, few studies have examined the effect of cognitive-behavioural group therapy (CBGT) on inflated responsibility. Aim: The aim of this study was to examine the effect of CBGT on OCD symptoms and responsibility beliefs. Methods: Thirty-six subjects meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for OCD were recruited to CBGT, and 28 of them completed 12 sessions. Subjects were assessed using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Responsibility Attitude Scale (RAS), and the Responsibility Interpretations Questionnaire (RIQ) at pre- and post-treatment. Results: Y-BOCS, RAS and RIQ (belief) scores were significantly improved at the end of the treatment. Conclusion: This study indicates that CBGT improves not only obsessive-compulsive symptoms but also inflated responsibility beliefs in patients with OCD.