The present study was conducted to predict the hot deformation behavior of the as-forged Nitinol 60 shape memory alloy by using the Arrhenius type, multiple-linear, and artificial neural network (ANN) models. The acquired flow stress data from isothermal hot compression tests in a temperature range of 650–850 °C under strain rate range of 0.01–1 s−1 were used to calculate the material constants for establishing the corresponding constitutive equations. Furthermore, a comparative study has been made on the capability of the aforementioned models to predict the high-temperature deformation behavior by comparing the prediction relative errors, average absolute relative error, and correlation coefficient. The results show that multiple-linear model predicts the flow behavior more accurately than the Arrhenius type model. The ANN model is much more efficient and has a better prediction power for the as-forged Nitinol 60 alloy than both the Arrhenius type and multiple-linear models.