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1 results

  • Lactate, histone lactylation and cancer hallmarks

  • Xinyu Lv, Yingying Lv, Xiaofeng Dai
  • Journal:
    Expert Reviews in Molecular Medicine / Volume 25 / 2023
    Published online by Cambridge University Press:
    09 January 2023, e7
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  • Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.