Field experiments were conducted over a 4-yr period to determine the influence of selected herbicides on ozone injury in tobacco (Nicotiana tabacum L.). Isopropalin (2,6-dinitro-N,N-dipropylcumidine), pebulate (S-propyl butylethylthiocarbamate), and diphenamid (N,N-dimethyl-2,2-diphenylacetamide) were applied at the recommended rates of 1.7, 4.5, and 4.5 kg/ha, respectively. Treatment of tobacco plants with isopropalin or diphenamid reduced oxidant injury for the first 2 to 4 weeks after transplanting, but not later in the season. Pebulate had no consistent affect on the sensitivity of tobacco to ozone.