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Neovaginal stenosis is one of the most reported complications of vaginoplasty. In this chapter, we review methods to prevent this complication during penile inversion vaginoplasty and the potential use of experimental techniques like biomaterials to avoid its development. Surgical and nonsurgical repair options are outlined for patients who experience neovaginal stenosis after vaginoplasty, as well as solutions to other potential postoperative complications that can arise after the procedure. These include dehiscence, postoperative bleeding, fistula formation, urinary symptoms, unique complications following intestinal vaginoplasty, and chronic pain.
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