Product Lifecycle Management (PLM) is one of the most business-critical IT backbones of manufacturing companies. It often consists of numerous, rigidly interwoven monolithic applications and is seen as synonymous with costly maintenance, lack of extensibility, and poor scalability. This paper proposes an approach for transforming a monolithic PLM landscape into a federated Domain and Data Mesh. This enhances semantic interoperability and enables data-driven use cases by treating data as first-class citizens. User-centric PLM domains moreover help to increase productivity in the workplace.