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1 results

  • Chapter 11 - Small Vessel Vasculitis and Selected Pediatric Vascular Diseases

  • from Section 4 - Vascular Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book:
    Pediatric Nephropathology & Childhood Kidney Tumors
    Published online:
    10 August 2023
    Print publication:
    09 March 2023, pp 213-230

  • Summary

    Small vessel vasculitides affecting the kidney destroy the integrity of the capillary wall and are grouped according to their appearance on immunofluorescence/immunohistochemistry. This chapter will concentrate on rapidly progressive glomerulonephritides of anti-glomerular basement membrane (GBM) and pauci-immune type, associated with anti-neutrophil cytoplasmic antibodies (ANCA). Both diseases usually cause a rapid decline in kidney function and show necrotizing, crescentic glomerulonephritis. Thrombotic microangiopathy (TMA) is a differential diagnosis of vasculitis. Childhood hypertension concludes this chapter.