Naptalam at 6.7 kg ae/ha applied with chloramben at 2.0 to 4.5 kg ae/ha was a safener for chloramben phytotoxicity to cucumber as expressed by increased dry weight in the greenhouse and yield in the field, but the protection was inadequate to be commercially acceptable. Naptalam applied in seed coatings also protected cucumber from chloramben phytotoxicity in the greenhouse but were ineffective in the field. Delaying chloramben application 24 to 72 h after naptalam application in the field increased the safening effect to a level that may be commercially acceptable. The safening effect was only to cucumber as effective weed control was achieved with chloramben and naptalam.