Objective: To assess the impact of guidelines on drug use issued
by a consensus conference on polycythemia vera held in Paris in June 1993.
32Phosphorus (32P) was recommended for patients over 70
and/or at risk, whereas pipobroman and hydroxyurea were recommended for
patients under 70.
Methods: A questionnaire was sent to all 119 departments of
nuclear medicine in France 1 year after the conference to find out whether and
how often they measured plasma volume and red cell mass (the recommended
diagnostic tests for polycythemia vera). Time-series analyses were performed
on sales of 32P, pipobroman (both virtually exclusively prescribed
for polycythemia), and hydroxyurea over a 4-year span (January
1992–December 1995).
Results: The average number of plasma volume determinations per
year did not change significantly after the conference (22 ± 26 before
vs 21 ± 25 after). 32P and pipobroman sales were stable
until July 1993, when 32P sales decreased while pipobroman sales
rose steadily. Hydroxyurea sales increased over the whole period with no
change in trend after the guidelines were published.
Conclusions: The guidelines apparently influenced clinical
practice since sales of drugs that are specifically used to treat polycythemia
vera showed clear changes in trend after publication of the guidelines. This
type of study seems to be an effective way of assessing the impact of
consensus conferences.