This article evaluates the level of interpersonal violence among human groups that inhabited northern Patagonia and southern Pampa (Argentina) during the Middle and Late Holocene, especially before contact with Europeans. We analyzed a particular type of trauma—blunt force trauma—in skull samples from several archaeological localities and compared our outcomes with those of a previous experimental work. The results agree with what is expected for small-scale societies within the regional historical and archaeological framework. The recorded percentages show a diachronic increase toward higher frequencies of this injury among males than among females and subadults, but the differences are not statistically significant. Generally, the levels of violence remained relatively constant during the period studied. Most of the injuries reflect low levels of damage, which allows us to hypothesize that the objects causing the injuries would be elements of everyday life. A smaller proportion show significant bone alteration that could be associated with weapons manufactured to exert violence or hunt animals.