This study examines to what extent phonetic reduction in different accents affects intelligibility for non-native (L2) listeners, and whether similar reduction processes in listeners’ first language (L1) facilitate the recognition and processing of reduced word forms in the target language. In two experiments, 80 Dutch-speaking and 80 Spanish-speaking learners of English were presented with unreduced and reduced pronunciation variants in native and non-native English speech. Results showed that unreduced words are recognized more accurately and more quickly than reduced words, regardless of whether these variants occur in non-regionally, regionally or non-native accented speech. No differential effect of phonetic reduction on intelligibility and spoken word recognition was observed between Dutch-speaking and Spanish-speaking participants, despite the absence of strong vowel reduction in Spanish. These findings suggest that similar speech processes in listeners’ L1 and L2 do not invariably lead to an intelligibility benefit or a cross-linguistic facilitation effect in lexical access.