Imazamox is an imidazolinone herbicide being developed for weed control in imidazolinone-resistant wheat (IMI-wheat) cultivars and various legume crops. In a series of studies conducted under a range of dryland cropping environments in the Pacific Northwest United States, imazamox applied to IMI-wheat or pea injured barley and canola grown 1 yr after imazamox treatment in low-rainfall, low–soil pH locations of Oregon. Injury was not observed in higher rainfall locations near Pullman, WA. Non–herbicide-resistant wheat planted 1 yr after IMI-wheat treated with imazamox was not injured. Of particular concern for imazamox carryover are low-rainfall areas with low-pH soils. Reduced soil moisture appears to limit imazamox degradation. Imazamox sorption is reduced in low-pH soils, which increases its bioavailability, thereby increasing the potential for injury to rotational crops such as barley, canola, and spring wheat.