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  • Chapter 15 - Which Cannabis Users Develop Psychosis?

  • from Part V - Cannabis and Psychosis
  • Edited by Deepak Cyril D'Souza, Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine, David Castle, University of Tasmania, Australia, Sir Robin Murray, Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
  • Book:
    Marijuana and Madness
    Published online:
    12 May 2023
    Print publication:
    01 June 2023, pp 148-155

  • Summary

    The fact that not all cannabis users will develop psychosis suggests that cannabis may exert its causal role only in pre-disposed individuals. However, since the number of people who use cannabis worldwide is so high, those who will eventually develop psychosis, whilst still a minority, represent a large number. The evidence indicates that different patterns of cannabis use have a different impact on the risk of developing psychosis, with young age at first use, and a higher frequency of use of high-potency types of cannabis indicated as the most important risk factors. Nonetheless, given the complex nature of the association between cannabis use and psychosis, it is hard to determine which cannabis users will eventually develop psychosis. The link between cannabis use and schizophrenia is unlikely to be just the result of a genetic predisposition, it is more likely the result of Gene x Environment inter-play.