This article looks at the translation and circulation of yogis’ learning in Persian medical and alchemical texts produced in South Asia. I suggest that looking at the non-religious environment allows for a more accurate understanding of the overall circulation of yogic knowledge and techniques in the Muslim society of South Asia. Furthermore, I suggest that the assimilation of yogis’ learning in Persian sources concerned not only Yoga but also other types of knowledge associated with yogis. Muslim physicians’ interest in yogis’ knowledge focused on one specific aspect: rasaśāstra “alchemy” and the mastery over the production of mercurial and metallic drugs. The technical and pragmatic focus of Persian medico-alchemical writings contributed to give views of yogis beyond the exotic and foreignizing category of the wonders of India. Medical writings helped to develop views of yogis as a socio-economic group involved in the transmission of a specific body of knowledge. This was an important shift away from the perspective of the ‘ajā’ib al-hind “wonders of India” as well as from the ways in which yogis were perceived in Sufi texts. New perspectives on yogis emerged when Persian-speaking scholars and readers in India needed more pragmatic representations of local groups, such as the physicians who were in the process of appropriating alchemical notions that were closely associated with the yogis.