The wavy leading edge (WLE, also known as leading edge protuberances) is a passive flow control device inspired by the humpback whale pectoral flippers. It reduces the flow of three-dimensional effects on wings and increases their aerodynamic performance at high angles of attack. Despite the numerous studies on its aerodynamic benefits, research on its possible applications is still incipient. Therefore, this article addresses an evaluation of the WLE effects on the aerodynamic performance of a winglet. A rectangular wing, a base smooth leading edge winglet, and a winglet with WLE were designed and manufactured for CFD simulations and wind tunnel measurements. The winglet with WLE increased the maximum aerodynamic efficiency, i.e. this configuration reduced the induced drag by increasing wingtip vortex dissipation at a given angle-of-attack. Such results were used in re-evaluations of the aerodynamic performance of an original agricultural aircraft initially configured with a multi-winglet device. The winglet with WLE showed to be effective at increasing the aircraft operational time and range under a simulated actual condition.