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1 results

  • Chapter 18 - Leukemia: Acute and Chronic

  • Edited by Laurie J. Mckenzie, University of Texas MD Anderson Cancer Center, Houston, Denise R. Nebgen, University of Texas MD Anderson Cancer Center, Houston
  • Book:
    Caring for the Female Cancer Patient
    Published online:
    23 October 2024
    Print publication:
    17 October 2024, pp 304-330

  • Summary

    Leukemias represent a range of bone marrow disorders that are broadly differentiated into acute and chronic. Acute leukemias, characterized by the proliferation of immature blood cells (blasts) and defined by peripheral blood or bone marrow blast percentage of 20 percent or more, are aggressive hematologic malignancies that are universally fatal without treatment. Chronic leukemias are mature leukemias with differentiated cells. Obstetric and gynecologic complications pose significant risk to the patient. Knowledge regarding uterine bleeding, fertility planning, and the management of the pregnant patient with leukemia are necessary in order to appropriately address these patients. In this chapter, we briefly review both acute and chronic leukemias, epidemiology, diagnosis and management, obstetric and gynecologic complications, teratogenicity of chemotherapies utilized in the treatment of each leukemia and finally detail our approach to the management of these patients.