To investigate the environmental history of the Tisza River (Hungary), we applied 14C and OSL dating methods for five parallel, neighboring cores from the flood plain area (Jászság Basin). Four major sedimentary layers were identified: meadow soil on the top (S1); silty-clay (S2); clayey-silt (S3) section; and fine sand (S4). 14C and OSL data were integrated into a synthetic age-depth model using the BACON software package. Formation of the S1 layer (depth: 0–1.0 m) falls in the Holocene, up to 10 kyrs cal BP, with moderate sedimentation rate (100 yr/cm aAR). The S2 layer (1.0–8.0 m depth) represent the entire Last Glacial to Upper Pleniglacial period (19–27 kyrs cal BP), with a much faster sedimentation (20 yr/cm aAr). The S3 section (8.0–17.0 m) represents a longer period (27–45 kyrs cal BP) with similar sedimentation rate (19 yr/cm aAr) as S2. These clayey silt layers fall into the Late Pleistocene/Middle Pleniglacial period, a period of nearly 18 kyrs of sedimentation resulting ∼9 m thick sediment. Our study delivered some new and important details about the surface evolution of the investigated Tiszasüly area. A missing part of about 10 kyrs period (between 10–19 kyrs cal BP) was revealed in the investigated synthetic cores.