Postemergence difenzoquat (1,2-dimethyl-3,5-diphenyl-1H-pyrazolium) for wild oat (Avena fatua L.) control in spring wheat (Triticum aestivum L.), durum wheat (Triticum durum Desf.), and barley (Hordeum vulgare L.) was evaluated in the field, greenhouse, and controlled environmental chamber. Wild oat control with difenzoquat was greater at the five- that at the three and one-half or two-leaf stages of growth. Barley tolerance to difenzoquat was excellent; however, spring wheat tolerance was influenced by cultivar. Durum wheat generally was more tolerant of difenzoquat than spring wheat. Tank mix combinations of broadleaf herbicides with difenzoquat had no effect on crop injury or wild oat control. Wild oat control with difenzoquat was greatest with adequate soil moisture, adequate fertility, warm air temperatures and high relative humidity. A simulated rainfall of 0.25 mm within ½ h or 1 mm within 4 h of application reduced wild oat control with difenzoquat.