Saflufenacil/dimethenamid-P is a relatively new prepackaged herbicide mixture that has the potential to provide enhanced weed control in soybean when tank-mixed with reduced doses of imazethapyr. Six field experiments were conducted over a 3-yr period (2011, 2012, and 2013) near Ridgetown and Exeter, Ontario, Canada, to determine the dose of imazethapyr, applied PRE, that must be added to saflufenacil/dimethenamid-P (245 g ai ha−1) to provide effective weed control in soybean. The predicted dose of imazethapyr PRE for 80% control of common lambsquarters, common ragweed, green foxtail, and velvetleaf 8 wk after soybean emergence (WAE) was 66, 180, 137, and 48 g ai ha−1, respectively. In contrast, when tank-mixed with saflufenacil/dimethenamid-P (245 g ha−1), the dose of imazethapyr PRE needed for 80% control of common lambsquarters, common ragweed, green foxtail, and velvetleaf was reduced to 11, 80, 48, and 18 g ha−1, respectively. The control of common lambsquarters, common ragweed, green foxtail, and velvetleaf was improved by 21, 23, 34, and 27%, respectively when saflufenacil/dimethenamid-P (245 g ha−1) was added to imazethapyr PRE. Imazethapyr at 104 g ha−1 resulted in soybean yield that was 95% of the weed-free control; however, when tank-mixed with saflufenacil/dimethenamid-P (245 g ha−1) only 54 g ha−1 of imazethapyr was required for the same yield level. Based on this study, PRE application of saflufenacil/dimethenamid-P with reduced doses of imazethapyr has the potential to improve soybean yield and provide acceptable weed control (≥ 80%); however, the extent that imazethapyr dose can be reduced is dependent upon weed community composition.