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The thalidomide disaster of 1958 and later isotretinoin from 1995 showed that drugs do reach the foetus and can cause harm. Even now, of the babies born with a recognised birth defect, drugs are implicated in 1–2%. As a result, there is a perception that any drug at any time in pregnancy could cause harm; however, this is not the case! It’s important to consider the benefit to the mother, the risk to the foetus and the form of administration. This chapter discusses some of the most common drug classes and whether and when they can be safely used in pregnancy.
Choice of antibiotic should be dictated by spectrum of activity, tissue penetration, potency and cost, and local patterns of infection. While advising prescribers to check with their local microbiologist or use their smartphone formulary app, the author describes the most common infectious disease presentations, and the first- and second-line antibiotic therapy based on national guidelines.
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