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2 results

  • Spontaneous regression of laryngeal squamous cell carcinoma

  • F Sipaul, B Ling, C Mason, A Keast
  • Journal:
    The Journal of Laryngology & Otology / Volume 129 / Issue 12 / December 2015
    Published online by Cambridge University Press:
    07 October 2015, pp. 1248-1250
    Print publication:
    December 2015
  • Background:

    Spontaneous regression of solid malignancy is extremely rare. It is virtually unheard of in the last half century in the published literature. The overwhelming majority of medical professionals do not know that this phenomenon exists.

    Case report:

    This paper reports such a case involving a patient with proven laryngeal squamous cell carcinoma in New Zealand. Whilst waiting for definitive treatment, he was afflicted with prolonged septicaemia secondary to peritonitis from percutaneous endoscopic gastrostomy tube insertion. Following a total laryngectomy, histology of the specimen did not contain any evidence of neoplasia.

    Conclusion:

    Based predominantly on work established by Dr William Coley, we believe that a period of prolonged pyrexia preceding definitive surgery contributed to this apparent ‘miracle’. The time may be ripe to further debate on whether the medical profession should consider pyrexia therapy as a last resort treatment for patients deemed incurable by conventional methods.

  • 7 - Venous thromboembolism in obstetrics and gynaecology

  • Edited by Ann Harper
  • Book:
    Haemorrhage and Thrombosis for the MRCOG and Beyond
    Published online:
    05 October 2014
    Print publication:
    01 June 2005, pp 90-110

  • Summary

    Venous thromboembolism (VTE) remains the major cause of mortality in association with pregnancy and childbirth and a source of morbidity. Many therapeutic agents may be used in the management of VTE. The choice of the agent and dosage is determined by the setting, balance of risks and benefit, and individual patient factors such as allergy or co-morbidity. Certain therapeutic agents include heparin, warfarin, dextran 70, aspirin and hirudin. The identification of risk factors for VTE provides an opportunity for prevention. The symptoms and signs of deep veins of lower limbs (DVT) include leg pain, swelling, tenderness, oedema, pyrexia, lower abdominal pain and elevated white cell count. Traditionally, unfractionated heparin (UFH) has been used in the initial management of VTE as such treatment reduces the risk of further thromboembolism compared with no treatment. Thromboprophylaxis is effective in reducing the incidence of VTE.