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1 results

  • Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium

  • LAURA S. FROST, VANDA S. LOPES, FRANK P. STEFANO, ALVINA BRAGIN, DAVID S. WILLIAMS, CLAIRE H. MITCHELL, KATHLEEN BOESZE-BATTAGLIA
  • Journal:
    Visual Neuroscience / Volume 30 / Issue 3 / May 2013
    Published online by Cambridge University Press:
    23 April 2013, pp. 55-64

  • Cathepsin-D (Cat-D) is a major proteolytic enzyme in phagocytic cells. In the retinal pigment epithelium (RPE), it is responsible for the daily degradation of photoreceptor outer segments (POSs) to maintain retinal homeostasis. Melanoregulin (MREG)-mediated loss of phagocytic capacity has been linked to diminished intracellular Cat-D activity. Here, we demonstrate that loss of MREG enhances the secretion of intermediate Cat-D (48 kDa), resulting in a net enhancement of extracellular Cat-D activity. These results suggest that MREG is required to maintain Cat-D homeostasis in the RPE and likely plays a protective role in retinal health. In this regard, in the Mregdsu/dsu mouse, we observe increased basal laminin. Loss of the Mregdsu allele is not lethal and therefore leads to slow age-dependent changes in the RPE. Thus, we propose that this model will allow us to study potential dysregulatory functions of Cat-D in retinal disease.