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premalignant

Breast Cancer Online (1)

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Evolution of PBL from normal epithelium to DCIS
S. K. Mohsin, D. C. Allred
Journal:

Breast Cancer Online / Volume 7 / Issue 11 / 16 November 2004

Published online by Cambridge University Press:

05 April 2005, e32

Print publication:

16 November 2004
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A large number of studies in the last three decades have identified only a handful of biological features in the evolution of human premalignant breast lesions (PBL). They have shown that PBL have a positive growth balance, which may be driven/regulated by oestrogen receptor, erbB-2, and p53. There is marked genetic diversity in PBL, and use of newer technologies such as SAGE, DNA microarrays, and high-throughput proteomics will significantly improve our understanding of evolution of PBL over the next decade.