The effect of bromoxynil on large crabgrass control by clethodim, sethoxydim, fluazifop-P, fluazifop-P plus fenoxaprop-P, and quizalofop-P was evaluated in 1996 and 1997 in bromoxynil-tolerant cotton and in fallow areas. Bromoxynil at 560 g ai/ha reduced large crabgrass control 4 weeks after treatment (WAT) when mixed with labeled rates of fluazifop-P, fluazifop-P plus fenoxaprop-P, or quizalofop-P. Control 9 WAT was reduced when bromoxynil was mixed with any of the graminicides. Antagonism with the mixtures was greatest with quizalofop-P, intermediate with fluazifop-P plus fenoxaprop-P and fluazifop-P, and least with clethodim and sethoxydim. Increasing the graminicide rate 50% in mixtures with bromoxynil alleviated antagonism only for clethodim. No antagonism was noted 9 WAT when bromoxynil was applied 3 d before or 3 d after application of clethodim or sethoxydim or when bromoxynil was applied 3 d after fluazifop-P plus fenoxaprop-P. Antagonism was observed when bromoxynil was applied 3 d before fluazifop-P plus fenoxaprop-P or when applied 3 d before or 3 d after fluazifop-P and quizalofop-P. Regardless of bromoxynil application, greatest yields were obtained from cotton treated with clethodim or sethoxydim. Bromoxynil applied 3 d before or 3 d after clethodim, sethoxydim, or fluazifop-P plus fenoxaprop-P did not reduce yield. Yield was reduced when bromoxynil was applied 3 d before or 3 d after application of fluazifop-P or quizalofop-P and when bromoxynil was mixed with any graminicide.