The aim of this paper is to give a full exposition of Leibniz’s mereological system. My starting point will be his papers on Real Addition, and the distinction between the containment and the part-whole relation. In the first part (§2), I expound the Real Addition calculus; in the second part (§3), I introduce the mereological calculus by restricting the containment relation via the notion of homogeneity which results in the parthood relation (this corresponds to an extension of the Real Addition calculus via what I call the Homogeneity axiom). I analyze in detail such a notion, and argue that it implies a gunk conception of (proper) part. Finally, in the third part (§4), I scrutinize some of the applications of the containment-parthood distinction showing that a number of famous Leibnizian doctrines depend on it.