This paper introduces a new Lagrangian surgery construction that generalizes Lalonde–Sikorav and Polterovich’s well-known construction, and combines this with Biran and Cornea’s Lagrangian cobordism formalism. With these techniques, we build a framework which both recovers several known long exact sequences (Seidel’s exact sequence, including the fixed point version and Wehrheim and Woodward’s family version) in symplectic geometry in a uniform way, and yields a partial answer to a long-term open conjecture due to Huybrechts and Thomas; this also involved a new observation which relates projective twists with surgeries.