This paper explores the origins of two different emergences of the Christian worldview concept, and their relationship to understandings of cultural conflict. It will offer an analysis of the historical, cultural, and theological context for each emergence. In both cases, worldview was what Ian Hunter has termed a “combat concept.” Section I of the paper will offer an overview of the origins of Christian worldview thinking in the late nineteenth century through the thought of James Orr (1844–1913) and Abraham Kuyper (1837–1920). Section II will deal with the second major emergence of Christian worldview as a combat concept in the 1970s, focusing on figures like Francis Schaeffer (1912–1984), Chuck Colson (1931–2012), and Nancy Pearcy (1951–). Both contexts exhibited increased cultural and religious pluralism, and conservative Christians displayed a heightened sense of ideological conflict. Worldview became a tool for differentiation from, and contention with, the “other.”